Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation.
Biochem Biophys Res Commun
; 514(3): 919-925, 2019 06 30.
Article
em En
| MEDLINE
| ID: mdl-31084926
ABSTRACT
Staphylococcal nuclease and tudor domain containing 1 (SND1) has multiple functions in a variety of cellular processes. Here, we assessed the effects of SND1 in cellular DNA damage after ionizing radiation (IR). Knocking down SND1 in the mouse-derived photoreceptor 661â¯W cell line markedly inhibited cell proliferation and increased apoptosis after IR treatment. After DNA damage, SND1 induced Ataxia telangiectasia mutated kinase (ATM) signaling to launch DNA repair. Defects of SND1 were associated with missing response to DNA damage signal to cell cycle checkpoints or DNA repair. The current findings reveal SND1 as a new regulatory factor in DNA damage response.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Células Fotorreceptoras Retinianas Cones
/
Reparo do DNA
/
Endonucleases
/
Pontos de Checagem da Fase G2 do Ciclo Celular
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2019
Tipo de documento:
Article