Synthesis of New ß-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities.
Iran J Pharm Res
; 18(1): 34-48, 2019.
Article
em En
| MEDLINE
| ID: mdl-31089342
ABSTRACT
Some new ß-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino ß-lactams in the presence of morpholine-4-carbonyl chloride. These novel ß-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC50 values.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Iran J Pharm Res
Ano de publicação:
2019
Tipo de documento:
Article