Evaluation of cefotaxime concentrations in rat cerebral areas and serum by microbiological method and HPLC.
Chemioterapia
; 6(2): 101-4, 1987 Apr.
Article
em En
| MEDLINE
| ID: mdl-3109749
ABSTRACT
The aim of the investigation was to verify the reliability and sensitivity of High Performance Liquid Chromatography (HPLC), compared to the classic microbiological method of plate diffusion, in evaluating cefotaxime concentrations in some cerebral areas and serum of the rat. The mean concentration of cefotaxime in the serum (after acute administration of 15 mg/kg i.m.) was 20 micrograms/ml with the microbiological method and 23 micrograms/ml with HPLC. No antibiotic was detectable, with both methods, in the cerebral areas. The results with both methods are in good accordance, although the HPLC technique is more sensitive and accurate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Cefotaxima
Limite:
Animals
Idioma:
En
Revista:
Chemioterapia
Ano de publicação:
1987
Tipo de documento:
Article