Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression.

Timaru-Kast, Ralph; Gotthardt, Philipp; Luh, Clara; Huang, Changsheng; Hummel, Regina; Schäfer, Michael K E; Thal, Serge C

Timaru-Kast, Ralph; Gotthardt, Philipp; Luh, Clara; Huang, Changsheng; Hummel, Regina; Schäfer, Michael K E; Thal, Serge C.

Afiliação

Timaru-Kast R; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Gotthardt P; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Luh C; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Huang C; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Hummel R; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Schäfer MKE; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Thal SC; Center for Molecular Surgical Research, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Front Aging Neurosci ; 11: 63, 2019.

Article em En | MEDLINE | ID: mdl-31105549

Palavras-chave

AT1 inhibition; M2 microglia polarization; aged; angiotensin II receptor type 1; candesartan; inflammation; neutrophil granulocyte; traumatic brain injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Aging Neurosci Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Aging Neurosci Ano de publicação: 2019 Tipo de documento: Article