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CIP2A overexpression in Taiwanese oral cancer patients.
Velmurugan, Bharath Kumar; Wang, Hsin-Kai; Chung, Chia-Min; Lee, Chien-Hsun; Huang, Lan-Ru; Yeh, Kun-Tu; Lin, Shu-Hui.
Afiliação
  • Velmurugan BK; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • Wang HK; Public Health Bureau, Tainan City Government, Tainan City, Taiwan.
  • Chung CM; Jenteh Junior College of Medicine, Nursing and Management, Taiwan.
  • Lee CH; Graduate Institute of BioMedical Sciences, China Medical University, Taichung, Taiwan.
  • Huang LR; Environment-Omics-Diseases Research Center, China Medical University Hospital, Taichung, Taiwan.
  • Yeh KT; Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan.
  • Lin SH; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Cancer Manag Res ; 11: 2589-2594, 2019.
Article em En | MEDLINE | ID: mdl-31114325
Introduction: Oral cancer is a prevalent form of cancer worldwide, particularly in Taiwan, and mechanisms involved in oral squamous cell carcinoma (OSCC) progression remain relatively unknown. Cancerous inhibitor of protein phosphatase 2A (CIP2A), an oncoprotein, is aberrantly expressed in many human malignant tumors including oral cancer. However, the expression and role played by CIP2A in oral cancer pathogenesis remain obscure. Methods: In this study, immunohistochemistry was used to analyze CIP2A expression between OSCC tissues and their adjacent noncancerous tissues. Furthermore, associations between CIP2A expression and histopathological parameters were investigated. Results: In this study, we showed that CIP2A was overexpressed in most of the OSCC tissues. High CIP2A expression was significantly associated with moderate/poor tumor differentiation (P=0.02). No significant association was found between CIP2A expression and other clinical parameters. Kaplan-Meier analysis revealed that high CIP2A expression showed poorer survival rates than those with low CIP2A expression (P=0.047). Multivariate Cox regression analysis indicated that CIP2A expression, N stage, American Joint Committee on Cancer stage and clinical therapy were independent prognostic factors for survival. Conclusion: Thus, our study suggests that CIP2A is an independent prognostic marker for OSCC and a novel target for OSCC treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Cancer Manag Res Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Cancer Manag Res Ano de publicação: 2019 Tipo de documento: Article