Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis.

Upadhyay, Akanksha; Chandrakar, Pragya; Gupta, Sampa; Parmar, Naveen; Singh, Sandeep Kumar; Rashid, Mamunur; Kushwaha, Pragati; Wahajuddin, Muhammad; Sashidhara, Koneni V; Kar, Susanta

Upadhyay, Akanksha; Chandrakar, Pragya; Gupta, Sampa; Parmar, Naveen; Singh, Sandeep Kumar; Rashid, Mamunur; Kushwaha, Pragati; Wahajuddin, Muhammad; Sashidhara, Koneni V; Kar, Susanta.

Afiliação

Upadhyay A; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Chandrakar P; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Gupta S; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Parmar N; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Singh SK; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Rashid M; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Kushwaha P; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Wahajuddin M; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Sashidhara KV; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.
Kar S; Academy of Scientific and Innovative Research (AcSIR) , Anusandhan Bhawan , New Delhi 110025 , India.

J Med Chem ; 62(11): 5655-5671, 2019 06 13.

Article em En | MEDLINE | ID: mdl-31124675

Assuntos

Antiprotozoários/síntese química; Antiprotozoários/farmacologia; Leishmaniose Visceral/tratamento farmacológico; Metronidazol/síntese química; Metronidazol/farmacologia; Quinolinas/química; Animais; Antiprotozoários/química; Antiprotozoários/farmacocinética; Técnicas de Química Sintética; Chlorocebus aethiops; Modelos Animais de Doenças; Leishmania donovani/efeitos dos fármacos; Leishmania donovani/fisiologia; Metronidazol/química; Metronidazol/farmacocinética; Ratos; Relação Estrutura-Atividade; Distribuição Tecidual; Células Vero

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Leishmaniose Visceral / Metronidazol / Antiprotozoários Limite: Animals Idioma: En Revista: J Med Chem Ano de publicação: 2019 Tipo de documento: Article

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