Chromatin topology in development and disease.
Curr Opin Genet Dev
; 55: 32-38, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-31125724
ABSTRACT
The discovery of domains of preferential interaction or Topologically Associating Domains (TADs) has provided a framework to understand the relation between enhancers and promoters within intricate regulatory landscapes. It has also enabled the conceptualization of the effect of non-coding structural variants on TADs structure and insulation and reveal new patho-mechanisms leading to disease. Here, we will review current knowledge on enhancer-promoter communication in relation to TAD structure. In particular, we will discuss how enhancer-promoter interaction dynamics is established within or outside of TADs. We will further provide an overview of how mutations affect the normal organization of the genome and how it impacts the normal ability of enhancers to induce transcription at their cognate promoters in disease. Finally, we will discuss the future directions to be explored to understand the mutual influences between 3D chromatin topology and gene regulation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Cromossomos
/
Predisposição Genética para Doença
/
Montagem e Desmontagem da Cromatina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Ano de publicação:
2019
Tipo de documento:
Article