Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).

Asquith, Christopher R M; Treiber, Daniel K; Zuercher, William J

Asquith, Christopher R M; Treiber, Daniel K; Zuercher, William J.

Afiliação

Asquith CRM; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: chris.asquith@unc.edu.
Treiber DK; Eurofins DiscoverX, 42501 Albrae Street, Fremont, CA 94538, USA.
Zuercher WJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: william.zuercher@unc.edu.

Bioorg Med Chem Lett ; 29(14): 1727-1731, 2019 07 15.

Article em En | MEDLINE | ID: mdl-31129055

Assuntos

Ciclina G/efeitos dos fármacos; Inibidores de Proteínas Quinases/uso terapêutico; Quinolinas/antagonistas & inibidores; Humanos; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

4-Anilinoquinazoline; 4-anilinoquinoline; Cyclin G associated kinase (GAK); Kinome selectivity; Mini-kinome panel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Inibidores de Proteínas Quinases / Ciclina G Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2019 Tipo de documento: Article

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