Post-weaning Exposure to High-Fat Diet Induces Kidney Lipid Accumulation and Function Impairment in Adult Rats.
Front Nutr
; 6: 60, 2019.
Article
em En
| MEDLINE
| ID: mdl-31131281
ABSTRACT
Aim:
We investigated the kidney morphofunctional consequences of high-fat diet intake since post-weaning in adult rats. MainMethods:
Male Wistar rats were divided into two groups ND (normal diet; n = 10) and HD (high-fat diet; n = 10). The high-fat diet was introduced post-weaned and animals were followed for 8 weeks. KeyFindings:
HD group did not change body weight gain even though food consumption has decreased with no changes in caloric consumption. The HD group showed glucose intolerance and insulin resistance. The glomerular filtration rate (GFR) was decreased in vivo (ND 2.8 ± 1.01; HD 1.1 ± 0.14 ml/min) and in the isolated perfusion method (34% of decrease). Renal histological analysis showed a retraction in glomeruli and an increase in kidney lipid deposition (ND 1.5 ± 0.17 HD 5.9 ± 0.06%). Furthermore, the high-fat diet consumption increased the pro-inflammatory cytokines IL-6 (ND 1,276 ± 203; HD 1,982 ± 47 pg/mL/mg) and IL-1b (ND 97 ± 12 HD 133 ± 5 pg/mL/mg) without changing anti-inflammatory cytokine IL-10.Significance:
Our study provides evidence that high-fat diet consumption leads to renal lipid accumulation, increases inflammatory cytokines, induces glomeruli retraction, and renal dysfunction. These damages observed in the kidney could be associated with an increased risk to advanced CKD in adulthood suggesting that reduction of high-fat ingestion during an early period of life can prevent metabolic disturbances and renal lipotoxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Nutr
Ano de publicação:
2019
Tipo de documento:
Article