CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.

Furusawa, Kotaro; Takasugi, Toshiyuki; Chiu, Yung-Wen; Hori, Yukiko; Tomita, Taisuke; Fukuda, Mitsunori; Hisanaga, Shin-Ichi

Furusawa, Kotaro; Takasugi, Toshiyuki; Chiu, Yung-Wen; Hori, Yukiko; Tomita, Taisuke; Fukuda, Mitsunori; Hisanaga, Shin-Ichi.

Afiliação

Furusawa K; Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa, Hachioji, Tokyo 192-0397.
Takasugi T; Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa, Hachioji, Tokyo 192-0397.
Chiu YW; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 and.
Hori Y; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 and.
Tomita T; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 and.
Fukuda M; Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Hisanaga SI; Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa, Hachioji, Tokyo 192-0397,. Electronic address: hisanaga-shinichi@tmu.ac.jp.

J Biol Chem ; 294(28): 10886-10899, 2019 07 12.

Article em En | MEDLINE | ID: mdl-31138646

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Proteínas do Citoesqueleto/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Doença de Alzheimer/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/fisiologia; Animais; Células COS; Chlorocebus aethiops; Proteínas do Citoesqueleto/genética; Endossomos/metabolismo; Estudo de Associação Genômica Ampla; Células HEK293; Humanos; Lisossomos/metabolismo; Neurônios/metabolismo; Placa Amiloide/metabolismo; Transporte Proteico; Proteólise; Vesículas Transportadoras/metabolismo

Palavras-chave

Alzheimer disease; CD2AP; CIN85; Rab; Rab7; amyloid precursor protein (APP); endosome; membrane trafficking; protein degradation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precursor de Proteína beta-Amiloide / Proteínas do Citoesqueleto / Proteínas Adaptadoras de Transdução de Sinal Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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