Quercetin-modified gold-palladium nanoparticles as a potential autophagy inducer for the treatment of Alzheimer's disease.
J Colloid Interface Sci
; 552: 388-400, 2019 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-31151017
At present, autophagic dysfunction has been considered to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, the activation of autophagy provides a potential means of eliminating the intracellular amyloid-ß (Aß) and slows down the neurotoxicity induced by Aß. Here, we synthesize a Quercetin (Qu) modified polysorbate 80 (P-80)-coated AuPd core-shell structure. Our results indicate that Concave cubic Qu@P-80@AuPd can activate autophagy of SH-SY5Y cells, promote the fusion of autophagosomes and lysosomes, accelerate the clearance of Aß, and protect SH-SY5Y cells from Aß-induced cytotoxicity damage. Furthermore, Concave cubic Qu@P-80@AuPd also has good biocompatibility and high blood-brain barrier (BBB) permeability. Therefore, we anticipate that Concave cubic Qu@P-80@AuPd will be used as a potential autophagy inducer to treat AD.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paládio
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Quercetina
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Autofagia
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Materiais Biocompatíveis
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Nanopartículas Metálicas
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Doença de Alzheimer
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Ouro
Limite:
Humans
Idioma:
En
Revista:
J Colloid Interface Sci
Ano de publicação:
2019
Tipo de documento:
Article