An overview on the synthetic and medicinal perspectives of indenopyrazoles.
Eur J Med Chem
; 178: 1-12, 2019 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-31167153
ABSTRACT
Indenopyrazole is emerging as one of the most promising and privileged scaffold in medicinal chemistry. This scaffold have been investigated for the development of novel derivatives and hybrids with other moieties and substituents exhibiting a wide range of medicinal properties like antimycobacterial, antipsychotic, antihypertensive, cannabinoid receptor affinity, anti-tumor, antimicrobial, etc. Furthermore, indenopyrazoles function as inhibitors in various mechanistic pathways which has been well established based on its anticancer potential. This review illustrates various synthetic strategies adopted and reveals the extensive significant biological properties of indenopyrazoles. Furthermore, ample scope is available for this scaffold which needs to be explored by medicinal chemists for the development of new potential drug candidates.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Indenos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2019
Tipo de documento:
Article