An overview on the synthetic and medicinal perspectives of indenopyrazoles.

ABSTRACT

Indenopyrazole is emerging as one of the most promising and privileged scaffold in medicinal chemistry. This scaffold have been investigated for the development of novel derivatives and hybrids with other moieties and substituents exhibiting a wide range of medicinal properties like antimycobacterial, antipsychotic, antihypertensive, cannabinoid receptor affinity, anti-tumor, antimicrobial, etc. Furthermore, indenopyrazoles function as inhibitors in various mechanistic pathways which has been well established based on its anticancer potential. This review illustrates various synthetic strategies adopted and reveals the extensive significant biological properties of indenopyrazoles. Furthermore, ample scope is available for this scaffold which needs to be explored by medicinal chemists for the development of new potential drug candidates.