Wild parsnip (Pastinaca sativa)-induced photosensitization.
Toxicon
; 167: 60-66, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31173794
ABSTRACT
Wild parsnip (Pastinaca sativa) has been associated with livestock and human photosensitization. An investigation of a natural occurrence of photosensitization of grazing horses identified wild parsnip as a possible cause. HPLC-MS and MS/MS analysis of this plant identified five furanocoumarins i.e., xanthotoxin, bergapten, isopimpinellin, imperatorin and a putative methoxyimperatorin. Goats fed this wild parsnip were largely unaffected. Xanthotoxin was not detected in the serum of parsnip-fed goats or in the serum of goats dosed orally or intravenous with purified xanthotoxin. Cutaneous application produced severe photodermatitis in goats and a horse consistent with topical exposure as the likely route to produce wild parsnip-induced photosensitivity. Wild parsnip-induced superficial necrotizing dermatitis was consistent with photodermatitis with no evidence of other allergic or inflammatory components.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Fotossensibilidade
/
Furocumarinas
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Fármacos Fotossensibilizantes
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Dermatite Fotoalérgica
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Pastinaca
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
2019
Tipo de documento:
Article