A standardized method for collection of human placenta samples in the age of functional magnetic resonance imaging.
Biotechniques
; 67(2): 45-49, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31184493
ABSTRACT
Current methods for placental tissue collection assess a delivered organ without direct functional correlates; therefore, the four-quadrant biopsy protocol utilized by many researchers may provide reasonable representation of tissue across a large organ, and offer a snapshot for molecular analysis of the placenta. However, the recent impetus to understand the placenta in real time, and the use of functional imaging to comprehend placental biology, warrants a different sampling approach. Here we present a method to standardize placental tissue collection in a format designed to facilitate correlation of in vivo function with ex vivo assessments. Additionally, we draw comparisons to the quadrant biopsy regimen, and highlight a pathological case of placental infarction detected by in utero imaging.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Biópsia
/
Imageamento por Ressonância Magnética
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Biotechniques
Ano de publicação:
2019
Tipo de documento:
Article