Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol.

Startek, Justyna B; Boonen, Brett; López-Requena, Alejandro; Talavera, Ariel; Alpizar, Yeranddy A; Ghosh, Debapriya; Van Ranst, Nele; Nilius, Bernd; Voets, Thomas; Talavera, Karel

Startek, Justyna B; Boonen, Brett; López-Requena, Alejandro; Talavera, Ariel; Alpizar, Yeranddy A; Ghosh, Debapriya; Van Ranst, Nele; Nilius, Bernd; Voets, Thomas; Talavera, Karel.

Afiliação

Startek JB; Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Boonen B; VIB Center for Brain & Disease Research, Leuven, Belgium.
López-Requena A; Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Talavera A; VIB Center for Brain & Disease Research, Leuven, Belgium.
Alpizar YA; Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Ghosh D; VIB Center for Brain & Disease Research, Leuven, Belgium.
Van Ranst N; Center for Microscopy and Molecular Imaging (CMMI), Laboratory of Microscopy, Université Libre de Bruxelles, Gosselies, Belgium.
Nilius B; Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Voets T; VIB Center for Brain & Disease Research, Leuven, Belgium.
Talavera K; Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Elife ; 82019 06 11.

Article em En | MEDLINE | ID: mdl-31184584

Assuntos

Membrana Celular/metabolismo; Colesterol/metabolismo; Canal de Cátion TRPA1/metabolismo; Sequência de Aminoácidos; Animais; Células CHO; Colesterol/química; Cricetinae; Cricetulus; Células HEK293; Humanos; Proteínas Luminescentes/genética; Proteínas Luminescentes/metabolismo; Microdomínios da Membrana/metabolismo; Camundongos; Microscopia de Fluorescência/métodos; Modelos Moleculares; Ligação Proteica; Domínios Proteicos; Homologia de Sequência de Aminoácidos; Canal de Cátion TRPA1/química; Canal de Cátion TRPA1/genética; Proteína Vermelha Fluorescente

Palavras-chave

CRAC motif; TRPA1; biochemistry; chemical biology; chemosensation; cholesterol; lipid raft; mouse; neuroscience; sensory neuron

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Colesterol / Canal de Cátion TRPA1 Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2019 Tipo de documento: Article

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