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Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease.
Ma, Yuying; Li, Linfeng; He, Shuai; Shang, Chengyou; Sun, Yang; Liu, Ning; Meek, Thomas D; Wang, Yaxin; Shang, Luqing.
Afiliação
  • Ma Y; College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , China.
  • Li L; Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas 77843 , United States.
  • He S; College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , China.
  • Shang C; College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , China.
  • Sun Y; Center of Basic Molecular Science, Department of Chemistry , Tsinghua University , Beijing 100084 , China.
  • Liu N; College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , China.
  • Meek TD; Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas 77843 , United States.
  • Wang Y; School of Life Sciences , Tianjin University , Tianjin 300110 , China.
  • Shang L; College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , China.
J Med Chem ; 62(13): 6146-6162, 2019 07 11.
Article em En | MEDLINE | ID: mdl-31184893
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas Virais / Acrilamidas / Cianoacrilatos / Enterovirus Humano A / Inibidores Enzimáticos Tipo de estudo: Prognostic_studies Idioma: En Revista: J Med Chem Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas Virais / Acrilamidas / Cianoacrilatos / Enterovirus Humano A / Inibidores Enzimáticos Tipo de estudo: Prognostic_studies Idioma: En Revista: J Med Chem Ano de publicação: 2019 Tipo de documento: Article