Position effects on promoter activity in Escherichia coli and their consequences for antibiotic-resistance determinants.
Biochem Soc Trans
; 47(3): 839-845, 2019 06 28.
Article
em En
| MEDLINE
| ID: mdl-31189732
ABSTRACT
The activity of any bacterial promoter is generally supposed to be set by its base sequence and the different transcription factors that bind in the local vicinity. Here, we review recent data indicating that the activity of the Escherichia coli lac operon promoter also depends upon its chromosomal location. Factors that affect promoter activity include the binding of nucleoid-associated proteins to neighbouring sequences, supercoiling and the activity of neighbouring promoters. We suggest that many bacterial promoters might be susceptible to similar position-dependent effects and we review recent data showing that the expression of mobile genes encoding antibiotic-resistance determinants is also location-dependent, both when carried on a bacterial chromosome or a conjugative plasmid.
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Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Resistência Microbiana a Medicamentos
/
Regiões Promotoras Genéticas
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Escherichia coli
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Efeitos da Posição Cromossômica
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2019
Tipo de documento:
Article