Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.

Poller, Birk; Woessner, Ralph; Barve, Avantika; Tillmann, Hanns-Christian; Vemula, Janardhana; Nica, Alexandra; Elbast, Walid; Schiller, Hilmar; End, Peter; Camenisch, Gian; Weiss, Markus

Poller, Birk; Woessner, Ralph; Barve, Avantika; Tillmann, Hanns-Christian; Vemula, Janardhana; Nica, Alexandra; Elbast, Walid; Schiller, Hilmar; End, Peter; Camenisch, Gian; Weiss, Markus.

Afiliação

Poller B; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Woessner R; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Barve A; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Tillmann HC; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Vemula J; IIS-Management, Novartis Healthcare Pvt. Ltd., Hyderabad, India.
Nica A; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Elbast W; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Schiller H; Novartis Institutes for Biomedical Research, Basel, Switzerland.
End P; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Camenisch G; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Weiss M; Novartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address: markus.weiss@novartis.com.

Pulm Pharmacol Ther ; 57: 101809, 2019 08.

Article em En | MEDLINE | ID: mdl-31195091

Assuntos

Inibidores de Hidroximetilglutaril-CoA Redutases/farmacocinética; Ácidos Indolacéticos/farmacologia; Transportador 1 de Ânion Orgânico Específico do Fígado/genética; Piridinas/farmacologia; Rosuvastatina Cálcica/farmacocinética; Sinvastatina/farmacocinética; Adulto; Interações Medicamentosas; Feminino; Genótipo; Voluntários Saudáveis; Humanos; Masculino; Pessoa de Meia-Idade; Transportadores de Ânions Orgânicos; Farmacogenética; Receptores Imunológicos/antagonistas & inibidores; Receptores de Prostaglandina/antagonistas & inibidores

Palavras-chave

Drug-drug interactions; Fevipiprant; Organic anion transporting polypeptide; Pharmacogenetics; Prostaglandin D(2) receptor 2 antagonist; Statin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Transportador 1 de Ânion Orgânico Específico do Fígado / Rosuvastatina Cálcica / Ácidos Indolacéticos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pulm Pharmacol Ther Ano de publicação: 2019 Tipo de documento: Article

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