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Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity.
Wang, Ning; Switalska, Marta; Wang, Li; Shaban, Elkhabiry; Hossain, Md Imran; El Sayed, Ibrahim El Tantawy; Wietrzyk, Joanna; Inokuchi, Tsutomu.
Afiliação
  • Wang N; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. wn12171982@sina.com.
  • Switalska M; Department of Materials Science and Engineering, Yingkou Institute of Technology, Yingkou 115014, China. wn12171982@sina.com.
  • Wang L; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12R. Weigla Street, 53-114 Wroclaw, Poland. switalska@iitd.pan.wroc.pl.
  • Shaban E; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. liwang_512@163.com.
  • Hossain MI; Department of Medicinal Chemistry, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. liwang_512@163.com.
  • El Sayed IET; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. shaban_nrc@yahoo.com.
  • Wietrzyk J; Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, 33 El-Bohouth Street, Dokki, Giza 12622, Egypt. shaban_nrc@yahoo.com.
  • Inokuchi T; Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. imranju7@yahoo.com.
Molecules ; 24(11)2019 Jun 05.
Article em En | MEDLINE | ID: mdl-31195640
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Indóis Limite: Animals / Humans Idioma: En Revista: Molecules Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Indóis Limite: Animals / Humans Idioma: En Revista: Molecules Ano de publicação: 2019 Tipo de documento: Article