Rational Design of Hybrid Peptides: A Novel Drug Design Approach.
Curr Med Sci
; 39(3): 349-355, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31209802
ABSTRACT
Peptides play crucial roles in various physiological and pathological processes. Consequently, the investigation of peptide-based drugs is a highlight in the research and development of new drugs. However, natural peptides are not always ideal choices for clinical application due to their limited number and sometimes cytotoxicity to normal cells. Aiming to gain stronger or specific or novel biological effects and overcome the disadvantages of natural peptides, artificial hybrid peptides have been designed by combining the sequence of two or more different peptides with varied biological functions. Compared to natural peptides, hybrid peptides have shown better therapeutic potentials against bacteria, tumors, and metabolic diseases. In this review, design strategies, structure features and recent development of hybrid peptides are summarized; future directions for the research and development of hybrid peptide drugs are also discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes de Fusão
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Engenharia de Proteínas
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Peptídeos Catiônicos Antimicrobianos
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Peptídeos Penetradores de Células
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Hipoglicemiantes
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Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Curr Med Sci
Ano de publicação:
2019
Tipo de documento:
Article