Circular RNA <i>circHIPK3</i> modulates autophagy via <i>MIR124-3p</i>-STAT3-PRKAA/AMPK&#945; signaling in STK11 mutant lung cancer.

Chen, Xiuyuan; Mao, Rui; Su, Wenmei; Yang, Xia; Geng, Qianqian; Guo, Chunfang; Wang, Zhuwen; Wang, Jun; Kresty, Laura A; Beer, David G; Chang, Andrew C; Chen, Guoan

Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer.

Chen, Xiuyuan; Mao, Rui; Su, Wenmei; Yang, Xia; Geng, Qianqian; Guo, Chunfang; Wang, Zhuwen; Wang, Jun; Kresty, Laura A; Beer, David G; Chang, Andrew C; Chen, Guoan.

Afiliação

Chen X; Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.
Mao R; Section of Thoracic Surgery, Department of Surgery, Rogel Cancer Center, University of Michigan, Ann Arbor, USA.
Su W; Cancer Center, Xinjiang Medical University, Urumqi, China.
Yang X; Department of Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Geng Q; The First Affiliated Hospital, Xian Jiaotong University, Xi'an, China.
Guo C; The First Affiliated Hospital, Xian Jiaotong University, Xi'an, China.
Wang Z; Section of Thoracic Surgery, Department of Surgery, Rogel Cancer Center, University of Michigan, Ann Arbor, USA.
Wang J; Section of Thoracic Surgery, Department of Surgery, Rogel Cancer Center, University of Michigan, Ann Arbor, USA.
Kresty LA; Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.
Beer DG; Section of Thoracic Surgery, Department of Surgery, Rogel Cancer Center, University of Michigan, Ann Arbor, USA.
Chang AC; Section of Thoracic Surgery, Department of Surgery, Rogel Cancer Center, University of Michigan, Ann Arbor, USA.
Chen G; Section of Thoracic Surgery, Department of Surgery, Rogel Cancer Center, University of Michigan, Ann Arbor, USA.

Autophagy ; 16(4): 659-671, 2020 04.

Article em En | MEDLINE | ID: mdl-31232177

Assuntos

Autofagia/fisiologia; Neoplasias Pulmonares/genética; MicroRNAs/genética; Proteínas Serina-Treonina Quinases/genética; RNA Circular/metabolismo; Transdução de Sinais; Quinases Proteína-Quinases Ativadas por AMP; Proteínas Quinases Ativadas por AMP/metabolismo; Autofagia/genética; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Humanos; Neoplasias Pulmonares/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais/genética; Transdução de Sinais/fisiologia

Palavras-chave

Cell death; HIPK3; STK11; ceRNA; circRNA; prognosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Transdução de Sinais / Proteínas Serina-Treonina Quinases / MicroRNAs / RNA Circular / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Autophagy Ano de publicação: 2020 Tipo de documento: Article

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