Oral ketamine alleviates behavioral despair without cognitive impairment in Wistar rats.
Behav Brain Res
; 372: 112058, 2019 10 17.
Article
em En
| MEDLINE
| ID: mdl-31247234
ABSTRACT
Ketamine is a non-competitive NMDA receptor antagonist used as a major anesthetic agent, especially in children. It has also been shown that at sub-anesthetic concentrations, ketamine has acute antidepressant properties. The rapid-onset nature of this effect makes it a promising alternative for classical antidepressants targeting the monoaminergic system. However, ketamine can lead to various cognitive side effects depending on the user/subject as well as its concentration and administration method, and it is still questionable whether this drug can be utilized as a reliable antidepressant. Here, we test the effects of continuous low dose oral ketamine on behavioral despair and spatial working memory in male Wistar rats. We found that 0.4â¯mg/day, but not 0.2â¯mg/day, ketamine in 30â¯ml juice has an antidepressant effect emerging in just 10 consecutive days as measured by means of forced swim tests without impairing spatial working memory performance in the Y-maze for as long as 30 days. These results suggest that, once clinically optimized, long-term use of low dose oral ketamine can produce antidepressant effects.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Depressão
/
Ketamina
/
Memória de Curto Prazo
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2019
Tipo de documento:
Article