Neural circular transcriptomes across mammalian species.
Genomics
; 112(2): 1162-1166, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31255695
ABSTRACT
Circular RNAs (circRNAs) have recently attracted significant interest in the realm of science and the evolution of species. Given the lack of information available on circRNAs due to various barriers related to sequencing techniques and bioinformatics tools, little regarding their function is known. It has been predicted that circRNAs contribute to gene expression regulation, but aside from a few specific cases, this contention has yet to be proven. Although the role of circRNAs in evolution remains elusive, from the few studies that have shown circRNA conservation in mammalian species, tissue specificity in brain regions, and the abundance of circRNAs in the brains of various species, the concept is becoming more likely with much gravitas. The proposed functional role of circRNAs being gene regulators is of great interest and would provide a basis to further understand not only the functional capabilities of organisms, but also the evolution of mammalian species.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Evolução Molecular
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Transcriptoma
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RNA Circular
Limite:
Animals
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Humans
Idioma:
En
Revista:
Genomics
Ano de publicação:
2020
Tipo de documento:
Article