AAV9-Mediated Cdk5 Inhibitory Peptide Reduces Hyperphosphorylated Tau and Inflammation and Ameliorates Behavioral Changes Caused by Overexpression of p25 in the Brain.

Xu, Miaojing; Huang, Yingwei; Song, Pingping; Huang, Yaowei; Huang, Wei; Zhang, Han-Ting; Hu, Yafang

Xu, Miaojing; Huang, Yingwei; Song, Pingping; Huang, Yaowei; Huang, Wei; Zhang, Han-Ting; Hu, Yafang.

Afiliação

Xu M; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Huang Y; Department of Neurology, the First Affiliated Hospital of Hainan Medical University, Haikou, China.
Song P; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Huang Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Huang W; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Zhang HT; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Hu Y; Department of Neurology, the First People's Hospital of Shunde, Southern Medical University, Guangzhou, Guangdong, P. R. China.

J Alzheimers Dis ; 70(2): 573-585, 2019.

Article em En | MEDLINE | ID: mdl-31256130

Assuntos

Encéfalo/metabolismo; Dependovirus; Proteínas do Tecido Nervoso/metabolismo; Fragmentos de Peptídeos/metabolismo; Fosfotransferases/biossíntese; Proteínas tau/metabolismo; Animais; Encéfalo/patologia; Dependovirus/genética; Expressão Gênica; Células HEK293; Humanos; Inflamação/genética; Inflamação/metabolismo; Inflamação/patologia; Injeções Intraventriculares; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Fosforilação/fisiologia; Fosfotransferases/genética; Proteínas tau/antagonistas & inibidores

Palavras-chave

Adeno-associated virus; Cdk5 inhibitory peptide; hyperphosphorylation of tau; neurodegeneration; p25

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Fosfotransferases / Encéfalo / Proteínas tau / Dependovirus / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Alzheimers Dis Ano de publicação: 2019 Tipo de documento: Article

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