Pragmatic evaluation of inhaled corticosteroid particle size formulations on asthma control.
Clin Exp Allergy
; 49(10): 1321-1327, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31264282
ABSTRACT
BACKGROUND:
Extra-fine particle formulations of inhaled corticosteroid (ICS) are associated with improved lung delivery.OBJECTIVES:
A pragmatic study to assess patient-reported outcomes after switching from fine to extra-fine particle ICS in persistent asthma.METHODS:
Twenty-four patients (mean age 48 year, FEV1 84%, ACQ 1.67) received 4 weeks run-in with a constant dose of fine particle ICS (mean dose 710 µg), followed by switching to an equivalent dose of extra-fine particle hydrofluoroalkane beclomethasone dipropionate (mean dose 355µg). Asthma control questionnaire (ACQ), the primary outcome and mini asthma quality of life questionnaire (mAQLQ) were measured pre- and post-run-in (baseline) and after 4 weeks and 8 weeks of switching.RESULTS:
Comparing pre- vs post-run-in, there were no differences for ACQ 1.67 vs 1.65 or AQLQ 5.08 vs 5.34. There were mean (95%CI) improvements (P < 0.001) from baseline after 8 weeks for ACQ -0.53 (-0.83, -0.23) and AQLQ 0.69 (0.35, 1.04), which exceeded the minimal clinically important difference (MCID) of 0.5 for both. There were also differences (P < 0.05) in domiciliary symptoms and reliever use. There were no significant changes at 8 weeks in lung function, FeNO or blood eosinophils.CONCLUSIONS:
Pragmatic switching from fine to extra-fine particle ICS at half the dose was associated with clinically relevant improvements in asthma control and quality of life, but not lung function or type 2 biomarkers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Asma
/
Inquéritos e Questionários
/
Corticosteroides
Tipo de estudo:
Clinical_trials
Aspecto:
Patient_preference
Limite:
Adolescent
/
Adult
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Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Exp Allergy
Ano de publicação:
2019
Tipo de documento:
Article