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Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury.
Cai, Weibin; Tan, Jing; Yan, Jianyun; Zhang, Lu; Cai, Xiaoqiang; Wang, Haiping; Liu, Fang; Ye, Maoqing; Cai, Chen-Leng.
Afiliação
  • Cai W; Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Biochemistry, Guangdong Engineering & Technology Research Center for Disease-Model Animals, Zhong
  • Tan J; Department of Biochemistry, Guangdong Engineering & Technology Research Center for Disease-Model Animals, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
  • Yan J; Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
  • Zhang L; Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine,
  • Cai X; Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
  • Wang H; Department of Biochemistry, Guangdong Engineering & Technology Research Center for Disease-Model Animals, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
  • Liu F; Cardiovascular Center, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Ye M; Shanghai Key Laboratory of Clinical Geriatric Medicine, Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Cai CL; Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine,
Cell Rep ; 28(1): 190-201.e3, 2019 07 02.
Article em En | MEDLINE | ID: mdl-31269439
ABSTRACT
The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely defined. Following apical resection of the neonatal mouse heart, we observed limited regeneration potential. Fate-mapping of Tbx18MerCreMer mice revealed that newly formed coronary vessels and a limited number of cardiomyocytes were derived from the T-box transcription factor 18 (Tbx18) lineage. However, further lineage tracing with SM-MHCCreERT2 and Nfactc1Cre mice revealed that the new smooth muscle and endothelial cells are in fact derivatives of pre-existing coronary vessels. Our data show that neonatal mouse heart can regenerate but that its potential is limited. Moreover, although epicardial cells are multipotent during embryogenesis, their contribution to heart repair through "stem" or "progenitor" cell conversion is minimal after birth. These observations suggest that early embryonic heart development and postnatal heart regeneration are distinct biological processes. Multipotency of epicardial cells is significantly decreased after birth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pericárdio / Regeneração / Células-Tronco / Vasos Coronários / Proteínas com Domínio T / Miócitos Cardíacos / Coração / Traumatismos Cardíacos Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pericárdio / Regeneração / Células-Tronco / Vasos Coronários / Proteínas com Domínio T / Miócitos Cardíacos / Coração / Traumatismos Cardíacos Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article