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COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake.
Behling, Felix; Ries, Vanessa; Skardelly, Marco; Gepfner-Tuma, Irina; Schuhmann, Martin; Ebner, Florian-Heinrich; Tabatabai, Ghazaleh; Bornemann, Antje; Schittenhelm, Jens; Tatagiba, Marcos.
Afiliação
  • Behling F; Department of Neurosurgery, Eberhard-Karls University, Hoppe-Seyler Street 3, Tuebingen, Germany. felix.behling@med.uni-tuebingen.de.
  • Ries V; Department of Neurosurgery, Eberhard-Karls University, Hoppe-Seyler Street 3, Tuebingen, Germany.
  • Skardelly M; Department of Neurosurgery, Eberhard-Karls University, Hoppe-Seyler Street 3, Tuebingen, Germany.
  • Gepfner-Tuma I; Department of Vascular Neurology, University Hospital Tuebingen, Eberhard Karls University, 72076, Tuebingen, Germany.
  • Schuhmann M; Department of Neurosurgery, Eberhard-Karls University, Hoppe-Seyler Street 3, Tuebingen, Germany.
  • Ebner FH; Eberhard-Karls University, Hoppe-Seyler Street 3, Tuebingen, Germany.
  • Tabatabai G; Interdisciplinary Division of Neuro-Oncology, Departments of Vascular Neurology and Neurosurgery, University Hospital Tuebingen, Eberhard Karls University, 72076, Tuebingen, Germany.
  • Bornemann A; Department of Neuropathology, Eberhard-Karls-University, 72076, Tuebingen, Germany.
  • Schittenhelm J; Department of Neuropathology, Eberhard-Karls-University, 72076, Tuebingen, Germany.
  • Tatagiba M; Department of Neurosurgery, Eberhard-Karls University, Hoppe-Seyler Street 3, Tuebingen, Germany.
Acta Neuropathol Commun ; 7(1): 105, 2019 07 11.
Article em En | MEDLINE | ID: mdl-31291992
ABSTRACT
Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2. This has also been investigated in vestibular schwannomas with promising results suggesting an antiproliferative effect and recently the intake has been recommended for vestibular schwannomas as a conservative treatment option. We constructed tissue microarrays from paraffin-embedded tissue samples of 1048 vestibular schwannomas and analyzed the expression of cyclooxygenase 2 and the proliferation marker MIB1 (Molecular Immunology Borstel) via immunohistochemistry together with clinical data (age, gender, tumor extension, prior radiotherapy, neurofibromatosis type 2, tumor recurrence, cyclooxygenase 2 responsive medication). Univariate analysis showed that cyclooxygenase 2 expression was increased with age, female gender, prior radiotherapy and larger tumor extension. MIB1 expression was also associated with higher cyclooxygenase 2 expression. Schwannomas of neurofibromatosis type 2 patients had lower cyclooxygenase 2 levels. Use of acetylsalicylic acid, non-steroidal anti-inflammatory drugs, glucocorticoids or other immunosuppressants did not show differences in cyclooxygenase 2 or MIB1 expression. Instead, cyclooxygenase 2 expression increases with tumor extension while MIB1 expression is not associated with tumor size. Overall, cyclooxygenase 2 expression is associated with proliferation but not influenced by regular intake of acetylsalicylic acid or other cyclooxygenase 2-responsive medications. Acetylsalicylic acid intake does not alter cyclooxygenase 2 expression and has no antiproliferative effect in vestibular.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Aspirina / Neuroma Acústico / Carga Tumoral / Proliferação de Células / Ciclo-Oxigenase 2 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Aspirina / Neuroma Acústico / Carga Tumoral / Proliferação de Células / Ciclo-Oxigenase 2 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2019 Tipo de documento: Article