In vitro characterization of MitE and MitB: Formation of N-acetylglucosaminyl-3-amino-5-hydroxybenzoyl-MmcB as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins.

Ogasawara, Yasushi; Nakagawa, Yo; Maruyama, Chitose; Hamano, Yoshimitsu; Dairi, Tohru

Ogasawara, Yasushi; Nakagawa, Yo; Maruyama, Chitose; Hamano, Yoshimitsu; Dairi, Tohru.

Afiliação

Ogasawara Y; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan. Electronic address: yogasawa@eng.hokudai.ac.jp.
Nakagawa Y; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan.
Maruyama C; Department of Bioscience, Fukui Prefectural University, Yoshida-Gun, Fukui 910-1195, Japan.
Hamano Y; Department of Bioscience, Fukui Prefectural University, Yoshida-Gun, Fukui 910-1195, Japan.
Dairi T; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan. Electronic address: dairi@eng.hokudai.ac.jp.

Bioorg Med Chem Lett ; 29(16): 2076-2078, 2019 08 15.

Article em En | MEDLINE | ID: mdl-31300341

Assuntos

Proteína de Transporte de Acila/química; Antibióticos Antineoplásicos/química; Proteínas de Bactérias/química; Carbono-Enxofre Ligases/química; Glicosiltransferases/química; Mitomicinas/biossíntese; Aminobenzoatos/química; Biocatálise; Hidroxibenzoatos/química; Mitomicinas/química; Streptomyces/enzimologia

Palavras-chave

Acyl carrier protein; Antibiotics; Biosynthesis; Glycosyltransferase; Mitomycin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Proteína de Transporte de Acila / Glicosiltransferases / Carbono-Enxofre Ligases / Mitomicinas / Antibióticos Antineoplásicos Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2019 Tipo de documento: Article

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