Factors related to early castration resistance in metastatic prostate cancer. Results from the National Prostate Cancer Registry in Spain. / Factores relacionados con la resistencia a la castración precoz en el cáncer de próstata metastásico. Resultados del Registro nacional de cáncer de próstata en España.
Actas Urol Esp (Engl Ed)
; 43(10): 562-567, 2019 Dec.
Article
em En, Es
| MEDLINE
| ID: mdl-31301868
ABSTRACT
INTRODUCTION:
The objective of the study was to determine the factors independently related with the development of castration resistance (CR) in prostate cancer (PC) in the medium term. MATERIAL ANDMETHODS:
155 patients diagnosed with metastatic PC with a follow-up of up to 39 months. Data taken from the National PC Registry. The evaluated variables were age, PSA, nadir PSA, Gleason, perineural invasion, TNM stages, and ADT type (intermittent/continuous).RESULTS:
Mean follow-up 26,2±13,4 months. 47.1% developed early CR, with mean time until onset of 12,2±8,7 months. Univariate analysis the mean PSA was correlated with CR (290±905,1 ng/mL in non CR, 519,1±1437,2 ng/mL in CR, P<.001), mean age (73,3±8,3 years in non CR, 69,1±9,3 in CR P=.01), mean PSA nadir (15,5±57,3ng/mL in non CR, 15,9±23,7 ng/mL in CR, p<0,001), Gleason (in ≥8, HR2,11. 95% CI 1.22-3.65, p=0.006), and T stage (in T3-T4, HR 2.85. 95% CI 1.57-5.19, P<.001). Multivariate analysis the independent variables associated to CR are age (HR 0.96. 95% CI 0.94-0.99, P=.01), PSA nadir (HR 1.65. 95% CI 1,43-1,91, P<.001), and T3-T4 stage (HR 2.11. 95% CI 1.10-4.04, P=.02).CONCLUSIONS:
PSA nadir and T3-T4 tumor stage at diagnosis are associated to an increased risk of developing CR. In addition, age at diagnosis is shown as a variable that decreases risk. Therefore, an older age would be associated with lower risk probability of CR in the medium term.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias de Próstata Resistentes à Castração
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
/
Es
Revista:
Actas Urol Esp (Engl Ed)
Ano de publicação:
2019
Tipo de documento:
Article