Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication.

Dujardin, Marie; Madan, Vanesa; Gandhi, Neha S; Cantrelle, François-Xavier; Launay, Hélène; Huvent, Isabelle; Bartenschlager, Ralf; Lippens, Guy; Hanoulle, Xavier

Dujardin, Marie; Madan, Vanesa; Gandhi, Neha S; Cantrelle, François-Xavier; Launay, Hélène; Huvent, Isabelle; Bartenschlager, Ralf; Lippens, Guy; Hanoulle, Xavier.

Afiliação

Dujardin M; University of Lille, CNRS, UMR 8576, UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Madan V; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, 69120 Heidelberg, Germany.
Gandhi NS; School of Mathematical Sciences and Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4000, Australia.
Cantrelle FX; University of Lille, CNRS, UMR 8576, UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Launay H; University of Lille, CNRS, UMR 8576, UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Huvent I; University of Lille, CNRS, UMR 8576, UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Bartenschlager R; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, 69120 Heidelberg, Germany.
Lippens G; University of Lille, CNRS, UMR 8576, UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Hanoulle X; University of Lille, CNRS, UMR 8576, UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France. Electronic address: xavier.hanoulle@univ-lille.fr.

J Biol Chem ; 294(35): 13171-13185, 2019 08 30.

Article em En | MEDLINE | ID: mdl-31315928

Assuntos

Ciclofilina A/metabolismo; RNA Viral/metabolismo; Proteínas não Estruturais Virais/metabolismo; Regulação Alostérica; Ciclofilina A/genética; Ciclofilina A/isolamento & purificação; Simulação de Dinâmica Molecular; Ressonância Magnética Nuclear Biomolecular; RNA Viral/química; Proteínas não Estruturais Virais/química; Proteínas não Estruturais Virais/isolamento & purificação; Replicação Viral

Palavras-chave

RNA replication; allosteric regulation; conformer ensemble; cyclophilin; hepatitis C virus (HCV); intrinsically disordered protein; nonstructural protein 5A (NS5A); nuclear magnetic resonance (NMR); prolyl isomerase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Viral / Proteínas não Estruturais Virais / Ciclofilina A Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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