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Evaluating the efficacy of a ferrous-ion-chelating peptide from Alaska pollock frame for the improvement of iron nutritional status in rats.
Ma, Xiaoming; Liu, Chuyi; Song, Wenshan; Che, Shuai; Wang, Changwei; Feng, Xiaomei; Li, Bafang; Dai, Yuankun.
Afiliação
  • Ma X; College of Food Science and Engineering, Ocean University of China, No. 5, Yu Shan Road, Qingdao, Shandong Province 266003, PR China. cleanclearbaby@163.com.
Food Funct ; 10(8): 4888-4896, 2019 Aug 01.
Article em En | MEDLINE | ID: mdl-31339120
ABSTRACT
This study aimed to investigate the effects of ferrous-ion-chelating peptides from Alaska pollock frames (APFP-Fe) on iron deficiency in anaemic rats. We hydrolysed the Alaska pollock frames to obtain a peptide with an average molecular weight of 822 Da. The bioavailability of APFP-Fe was tested using animal experiments. Wistar rats were randomly divided into six groups an iron deficiency control group, a normal control group, and iron deficiency groups treated with ferrous sulfate (FeSO4) or low-, medium-, or high-dose APFP-Fe. Rats in the iron deficiency groups were fed an iron-deficient diet to establish the iron deficiency anaemia (IDA) model. After the model was established, different iron supplements were given to rats once per day via intragastric administration for 21 days. The results showed that APFP-Fe had restorative effects, returning the body weight, weight gain, height, and haematological parameters in IDA rats to normal levels. In addition, compared with FeSO4, APFP-Fe promoted significant weight gain and effectively improved haemoglobin, serum iron and transferrin levels, and recovery of the capacity of iron binding with transferrin, especially at the medium and high doses. These findings suggest that APFP-Fe is an effective source of iron for improving the iron nutritional status in IDA rats and shows promise as a new source of iron supplementation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Resíduos / Compostos Ferrosos / Quelantes / Anemia Ferropriva / Ferro Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Food Funct Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Resíduos / Compostos Ferrosos / Quelantes / Anemia Ferropriva / Ferro Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Food Funct Ano de publicação: 2019 Tipo de documento: Article