Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer.

Magen, Assaf; Das Sahu, Avinash; Lee, Joo Sang; Sharmin, Mahfuza; Lugo, Alexander; Gutkind, J Silvio; Schäffer, Alejandro A; Ruppin, Eytan; Hannenhalli, Sridhar

Magen, Assaf; Das Sahu, Avinash; Lee, Joo Sang; Sharmin, Mahfuza; Lugo, Alexander; Gutkind, J Silvio; Schäffer, Alejandro A; Ruppin, Eytan; Hannenhalli, Sridhar.

Afiliação

Magen A; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1
Das Sahu A; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; Department of Biostatistics and Computational Biology, Harvard School of Public Health, Boston, MA, USA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Lee JS; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sharmin M; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; Department of Genetics, Stanford University, Stanford, CA, USA.
Lugo A; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA.
Gutkind JS; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Schäffer AA; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: alejandro.schaffer@nih.gov.
Ruppin E; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: eytan.ruppin@nih.gov.
Hannenhalli S; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: sridhar@umiacs.umd.edu.

Cell Rep ; 28(4): 938-948.e6, 2019 07 23.

Article em En | MEDLINE | ID: mdl-31340155

Assuntos

Regulação Neoplásica da Expressão Gênica; Neoplasias/genética; Mutações Sintéticas Letais/genética; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Carcinogênese/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Genes Neoplásicos; Humanos; Neoplasias/tratamento farmacológico; Especificidade de Órgãos/genética; Análise de Sobrevida

Palavras-chave

cancer stratification; data mining; drug response; gene interactions; patient survival analysis; synthetic lethality

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Mutações Sintéticas Letais / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article

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