The antimicrobial efficacy of zinc doped phosphate-based glass for treating catheter associated urinary tract infections.
Mater Sci Eng C Mater Biol Appl
; 103: 109868, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31349427
ABSTRACT
In this study, a series of phosphate-based glasses; (P2O5)50(Na2O)20(CaO)30-x (ZnO)x were prepared with increasing concentration of zinc oxide to determine the antimicrobial effect against clinically relevant microorganisms. The addition of 1 and 3â¯mol% zinc oxide decreased glass degradation however a higher dissolution rate was observed for 5 and 10â¯mol% ZnO. The antimicrobial results showed a concentration dependent effect on the viability of microorganisms. When in direct contact zinc doped glasses showed a complete kill, within 24â¯h, against Escherichia coli and a significant (pâ¯<â¯0.01) kill was observed against Staphylococcus aureus however the effect of dissolution products was not seen until 48â¯h. Furthermore, the cytotoxic studies showed no toxic effects on the viability of uroepithelial cells. This study has shown that zinc doped phosphate-based glasses can potentially be used to prevent/treat catheter associated urinary tract infections.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Fosfatos
/
Infecções Estafilocócicas
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Staphylococcus aureus
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Infecções Urinárias
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Zinco
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Escherichia coli
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Infecções por Escherichia coli
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Catéteres
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Vidro
/
Antibacterianos
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Ano de publicação:
2019
Tipo de documento:
Article