Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila.

Ghimire, Saurav; Terhzaz, Selim; Cabrero, Pablo; Romero, Michael F; Davies, Shireen A; Dow, Julian A T

Targeted renal knockdown of Na⁺/H⁺ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila.

Ghimire, Saurav; Terhzaz, Selim; Cabrero, Pablo; Romero, Michael F; Davies, Shireen A; Dow, Julian A T.

Afiliação

Ghimire S; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Terhzaz S; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Cabrero P; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Romero MF; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Davies SA; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Dow JAT; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Am J Physiol Renal Physiol ; 317(4): F930-F940, 2019 10 01.

Article em En | MEDLINE | ID: mdl-31364377

Assuntos

Túbulos de Malpighi/metabolismo; Nefrolitíase/genética; Nefrolitíase/metabolismo; Fosfoproteínas/metabolismo; Trocadores de Sódio-Hidrogênio/metabolismo; Ácido Úrico/metabolismo; Alopurinol/farmacologia; Animais; Modelos Animais de Doenças; Drosophila melanogaster; Inibidores Enzimáticos/farmacologia; Técnicas de Silenciamento de Genes; Proteínas dos Microfilamentos/metabolismo; Mutação/genética; Nefrolitíase/induzido quimicamente

Palavras-chave

Drosophila; Malpighian tubule; nephrolithiasis; sex-determining region Y protein-interacting protein-1; uric acid stones

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Ácido Úrico / Trocadores de Sódio-Hidrogênio / Nefrolitíase / Túbulos de Malpighi Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Am J Physiol Renal Physiol Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google