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Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity in Caenorhabditis elegans.
Kim, So-Hyeon; Kim, Bo-Kyoung; Park, Suhyeon; Park, Sang-Kyu.
Afiliação
  • Kim SH; Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Republic of Korea.
  • Kim BK; Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Republic of Korea.
  • Park S; Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Republic of Korea.
  • Park SK; Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Republic of Korea.
Oxid Med Cell Longev ; 2019: 2860642, 2019.
Article em En | MEDLINE | ID: mdl-31379987
Phosphatidylcholine is one of the major phospholipids comprising cellular membrane and is known to have several health-promoting activities, including the improvement of brain function and liver repair. In this paper, we examine the in vivo effect of dietary supplementation with phosphatidylcholine on the response to environmental stressors and aging in C. elegans. Treatment with phosphatidylcholine significantly increased the survival of worms under oxidative stress conditions. However, there was no significant difference in response to stresses caused by heat shock or ultraviolet irradiation. Oxidative stress is believed to be one of the major causal factors of aging. Then, we examined the effect of phosphatidylcholine on lifespan and age-related physiological changes. Phosphatidylcholine showed a lifespan-extending effect and a reduction in fertility, possibly as a tradeoff for long lifespan. Age-related decline of motility was also significantly delayed by supplementation with phosphatidylcholine. Interestingly, the expressions of well-known longevity-assuring genes, hsp-16.2 and sod-3, were significantly upregulated by dietary intervention with phosphatidylcholine. DAF-16, a transcription factor modulating stress response genes, was accumulated in the nucleus by phosphatidylcholine treatment. Increase of the ROS level with phosphatidylcholine suggests that the antioxidant and lifespan-extending effects are due to the hormetic effect of phosphatidylcholine. Phosphatidylcholine also showed a protective effect against amyloid beta-induced toxicity in Alzheimer's disease model animals. Experiments with long-lived mutants revealed that the lifespan-extending effect of phosphatidylcholine specifically overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16. These findings showed the antioxidant and antiaging activities of phosphatidylcholine for the first time in vivo. Further studies focusing on the identification of underlying cellular mechanisms involved in the antiaging effect will increase the possibility of using phosphatidylcholine for the development of antiaging therapeutics.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilcolinas / Peptídeos beta-Amiloides / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Fatores de Transcrição Forkhead / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Oxid Med Cell Longev Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilcolinas / Peptídeos beta-Amiloides / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Fatores de Transcrição Forkhead / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Oxid Med Cell Longev Ano de publicação: 2019 Tipo de documento: Article