The effect of prescribed exercise volume on biomarkers of chronic stress in postmenopausal women: Results from the Breast Cancer and Exercise Trial in Alberta (BETA).
Prev Med Rep
; 15: 100960, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31384527
ABSTRACT
There is epidemiologic and biologic evidence for a role of stress in breast cancer etiology and physical activity mitigates the negative effects of stress. We examined the potential for a dose-response relationship between two volumes of aerobic exercise and biomarkers of chronic stress in post-menopausal women. The Breast Cancer and Exercise Trial in Alberta is a randomized controlled trial with post-menopausal women randomized to either a MODERATE (150â¯min per week) or HIGH (300â¯min per week) volume of exercise over a one year intervention period. Fasting serum concentrations of cortisol, cortisone, corticosterone and 11-deoxycortisol at baseline, 12â¯months (the end of the intervention), and 24â¯months. Intention-to-treat analyses were performed using general linear models, adjusted for baseline biomarker concentrations. There were modest but non-statistically significant decreases in cortisol (HIGH -4%, 95% CI -7%, 2%; MODERATE -1%, 95% CI -14%, 4%) and corticosterone (HIGH -4%, 95% CI -12%, 6%; MODERATE -5%, 95% CI -14%, 4%) concentrations for both exercise groups between baseline and 12â¯months, and no difference in cortisone concentrations. Intention-to-treat analysis of 386 (97%) participants showed no statistically significant group differences for changes in biomarker levels at 12â¯months. Between baseline and 12â¯months, there were no differences in cortisol or cortisone and, at 24â¯months all stress hormone levels increased to near-baseline levels with no significant differences between the two intervention groups.
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01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Prev Med Rep
Ano de publicação:
2019
Tipo de documento:
Article