Antiviral activity of merimepodib against foot and mouth disease virus in vitro and in vivo.
Mol Immunol
; 114: 226-232, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31386979
ABSTRACT
Foot and mouth disease virus (FMDV), a member of family Picornaviridae, belongs to the genus Aphthovirus, which causes foot and mouth disease (FMD), a highly transmissible disease that affects cloven-hoof animals. In spite of the fact that efficient vaccines are available, effective antiviral molecules for FMD are needed to reduce viral infection during early stages of infection. In this study, merimepodib was found to efficiently inhibit FMDV replication in a dose-dependent manner. The 50% inhibitory concentration (IC50) of merimepodib antiviral activity against two distinct FMDV strains (O/MYA98/BY/2010 and A/GD/MM/CHA/2013) was estimated to be 7.859 and 2.876⯵M, respectively, while the 50% cytotoxic concentration (CC50) of merimepodib was found to be 47.74⯵M. Furthermore, treatment with 30⯵g merimepodib efficiently prolonged the survival time of suckling mice infected with FMDV. Taken together, these results suggested that merimepodib has the potential to be a novel antiviral agent against FMDV.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Compostos de Fenilureia
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Carbamatos
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Vírus da Febre Aftosa
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Febre Aftosa
Limite:
Animals
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2019
Tipo de documento:
Article