Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans.

Weisová, Petronela; Cehlár, Ondrej; Skrabana, Rostislav; Zilková, Monika; Filipcík, Peter; Kovácech, Branislav; Prcina, Michal; Wojciaková, Lubica; Fialová, Lubica; Smolek, Tomás; Kontseková, Eva; Zilka, Norbert; Novák, Michal

Weisová, Petronela; Cehlár, Ondrej; Skrabana, Rostislav; Zilková, Monika; Filipcík, Peter; Kovácech, Branislav; Prcina, Michal; Wojciaková, Lubica; Fialová, Lubica; Smolek, Tomás; Kontseková, Eva; Zilka, Norbert; Novák, Michal.

Afiliação

Weisová P; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic. weisova@axon-neuroscience.eu.
Cehlár O; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Skrabana R; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Zilková M; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Filipcík P; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Kovácech B; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Prcina M; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Wojciaková L; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Fialová L; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Smolek T; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Kontseková E; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Zilka N; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
Novák M; Axon Neuroscience SE, Arch. Makariou & Kalogreon 4, Larnaca, Cyprus.

Acta Neuropathol Commun ; 7(1): 129, 2019 08 07.

Article em En | MEDLINE | ID: mdl-31391090

Assuntos

Anticorpos Monoclonais/metabolismo; Microtúbulos/metabolismo; Neurônios/metabolismo; Proteoglicanas/metabolismo; Proteínas tau/metabolismo; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Sequência de Aminoácidos; Animais; Anticorpos Monoclonais/administração & dosagem; Sítios de Ligação/fisiologia; Encéfalo/efeitos dos fármacos; Encéfalo/patologia; Sistemas de Liberação de Medicamentos/tendências; Espaço Extracelular/efeitos dos fármacos; Espaço Extracelular/genética; Espaço Extracelular/metabolismo; Feminino; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Microtúbulos/efeitos dos fármacos; Microtúbulos/genética; Neurônios/efeitos dos fármacos; Gravidez; Estrutura Secundária de Proteína; Estrutura Terciária de Proteína; Proteínas tau/genética

Palavras-chave

Alzheimer's disease; Heparan sulfate; Immunotherapy; Mechanism of action; Spreading; Tau

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoglicanas / Proteínas tau / Microtúbulos / Anticorpos Monoclonais / Neurônios Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2019 Tipo de documento: Article

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