Catalytic Amination of ß-(Hetero)arylethyl Ethers by Phosphazene Base t-Bu-P4.
Org Lett
; 21(17): 6695-6699, 2019 09 06.
Article
em En
| MEDLINE
| ID: mdl-31403305
ABSTRACT
We describe the catalytic amination of ß-(hetero)arylethyl ethers with amines using the organic superbase t-Bu-P4 to obtain ß-(hetero)arylethylamines. The reaction has a broad substrate scope and allows the transformations of electron-deficient and electron-neutral ß-(hetero)arylethyl ethers with various amines including pyrrole, N-alkylaniline, diphenylamine, aniline, indole, and indoline derivatives. Mechanistic studies indicate a two-reaction pathway of MeOH elimination from the substrate to form a (hetero)arylalkene followed by the hydroamination of the alkene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2019
Tipo de documento:
Article