Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy.
J Neurophysiol
; 122(3): 1238-1253, 2019 09 01.
Article
em En
| MEDLINE
| ID: mdl-31411933
ABSTRACT
Cerebral palsy (CP) is the most common motor disability in children. Much of the previous research on CP has focused on reducing the severity of brain injuries, whereas very few researchers have investigated the cause and amelioration of motor symptoms. This research focus has had an impact on the choice of animal models. Many of the commonly used animal models do not display a prominent CP-like motor phenotype. In general, rodent models show anatomically severe injuries in the central nervous system (CNS) in response to insults associated with CP, including hypoxia, ischemia, and neuroinflammation. Unfortunately, most rodent models do not display a prominent motor phenotype that includes the hallmarks of spasticity (muscle stiffness and hyperreflexia) and weakness. To study motor dysfunction related to developmental injuries, a larger animal model is needed, such as rabbit, pig, or nonhuman primate. In this work, we describe and compare various animal models of CP and their potential for translation to the human condition.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
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Paralisia Cerebral
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Desenvolvimento Infantil
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Modelos Animais de Doenças
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Transtornos Motores
Limite:
Animals
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Child
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Humans
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
2019
Tipo de documento:
Article