miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt-ß-catenin pathway.

Liu, Qiang; Guan, Yanlei; Li, Zhenhang; Wang, Yao; Liu, Yu; Cui, Run; Wang, Yunjie

Liu, Qiang; Guan, Yanlei; Li, Zhenhang; Wang, Yao; Liu, Yu; Cui, Run; Wang, Yunjie.

Afiliação

Liu Q; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Guan Y; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Li Z; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Wang Y; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Liu Y; Department of Cardiac Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Cui R; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Wang Y; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.

J Exp Clin Cancer Res ; 38(1): 358, 2019 Aug 16.

Article em En | MEDLINE | ID: mdl-31419987

Assuntos

Neoplasias Encefálicas/patologia; Transição Epitelial-Mesenquimal; Receptores Frizzled/metabolismo; Glioblastoma/patologia; MicroRNAs/genética; Proteínas Wnt/metabolismo; beta Catenina/metabolismo; Animais; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Proliferação de Células; Estudos de Coortes; Feminino; Seguimentos; Receptores Frizzled/genética; Regulação Neoplásica da Expressão Gênica; Glioblastoma/genética; Glioblastoma/metabolismo; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; Prognóstico; Taxa de Sobrevida; Células Tumorais Cultivadas; Proteínas Wnt/genética; Ensaios Antitumorais Modelo de Xenoenxerto; beta Catenina/genética

Palavras-chave

EMT; FZD7; GBM; Mesenchymal phenotype; Wntß-catenin pathway; miR-504

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / MicroRNAs / Proteínas Wnt / Beta Catenina / Receptores Frizzled / Transição Epitelial-Mesenquimal Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2019 Tipo de documento: Article

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