Hypertension and progressive supranuclear palsy.
Parkinsonism Relat Disord
; 66: 166-170, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31420308
ABSTRACT
BACKGROUND:
The epidemiologic evidence of whether hypertension is associated with Progressive Supranuclear Palsy (PSP) is inconsistent. The ENGENE-PSP case-control study determined various PSP risk factors including whether hypertension preceded PSP onset.METHODS:
Incident PSP cases per NINDS-PSP criteria and age-, sex-, race- matched controls were recruited from similar North American geographic areas. All study participants were administered standardized interviews to obtain data on demographics, medical history and medications. STATISTICS We used univariate and multivariate conditional logistic regression models to measure the associations between PSP and the following predictor variables education level, hypertension, comorbid vascular conditions (diabetes mellitus and hyperlipidemia), and classes of anti-hypertensive medications using odds ratios and 95% confidence intervals.RESULTS:
There were significant associations seen between PSP and hypertension (OR 1.569; 95% CI 1.129-2.181; p-valueâ¯=â¯0.007), education level (OR 0.733; 95% CI 0.637-0.843; p-value<0.001) and beta-blocker use (OR 2.000; 95% CI 1.053-3.799; p-valueâ¯=â¯0.034). However, in the multi-variate analysis hypertension (OR 1.492; 95% CI 1.045-2.129; p-valueâ¯=â¯0.027) and education level (OR 0.730; 95% CI 0.633-0.841; p-value<0.001) were the only significant associations.CONCLUSION:
These results suggest that there is a modest, yet significant association between hypertension and PSP. Further studies will be needed to better understand the pathophysiological basis for this finding.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paralisia Supranuclear Progressiva
/
Hipertensão
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Parkinsonism Relat Disord
Ano de publicação:
2019
Tipo de documento:
Article