Your browser doesn't support javascript.
loading
The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative.
Mabkhot, Yahia N; Khaled, Jamal M A; Sultan, Mujeeb A S; Alharbi, Naiyf S H A; Al-Showiman, Salim S; Ghabbour, Hazem A; Alsayari, Abdulrahman; Muhsinah, Abdullatif Bin; Algarni, H.
Afiliação
  • Mabkhot YN; Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia. Electronic address: ygaber@kku.edu.sa.
  • Khaled JMA; Department of Botany and Microbiology, College of Science, King Saud University, Saudi Arabia. Electronic address: gkhaled@ksu.edu.sa.
  • Sultan MAS; Department of Chemistry, College of Sciences, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Department of Pharmacy, Faculty of Medical Sciences, Aljanad University, Taiz, Republic of Yemen. Electronic address: Alhosami1983@yahoo.co.uk.
  • Alharbi NSHA; Department of Botany and Microbiology, College of Science, King Saud University, Saudi Arabia. Electronic address: nalharbi1@KSU.EDU.SA.
  • Al-Showiman SS; Department of Chemistry, Science College, King Saud University, P.O. Box 2455, Saudi Arabia. Electronic address: showiman@KSU.EDU.SA.
  • Ghabbour HA; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt.
  • Alsayari A; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia. Electronic address: alsayari@kku.edu.sa.
  • Muhsinah AB; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia. Electronic address: ajmohsnah@kku.edu.sa.
  • Algarni H; Department of Physics, Faculty of Sciences, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia; Research Centre for Advanced Materials Science (RCAMS), King Khalid University, Abha, 61413131413, P.O. Box 9004, Saudi Arabia. Electronic address: halgarni@kku.edu.sa.
Bioorg Chem ; 91: 103157, 2019 10.
Article em En | MEDLINE | ID: mdl-31421509
ABSTRACT
The compound diethyl 2,2'-(thiocarbonyl-bis(sulfanediyl))-diacetate 4 belongs to the trithiocarbonate class containing a trithiocarbonate function group flanked by ethyl acetate. In this procedure, a novel economic synthesis route to obtain compound 4 is described. This compound proved to possess broad-spectrum antimicrobial activity both in vitro and in vivo, and could be used as a lead compound. It is worth mentioning that this compound has been patented [No. US 9,988,348 B1; date of patent June 5, 2018].
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tionas / Bactérias / Fungos / Anti-Infecciosos Tipo de estudo: Health_economic_evaluation Limite: Animals Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tionas / Bactérias / Fungos / Anti-Infecciosos Tipo de estudo: Health_economic_evaluation Limite: Animals Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article