A potential role of triple therapy for asthma patients.
Expert Rev Respir Med
; 13(11): 1079-1085, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31422716
ABSTRACT
Introduction:
The use of LAMAs in asthma is now supported by pharmacological and clinical evidence, whereas the effectiveness of therapy with ICS/LABA/LAMA fixed dose combinations in patients with asthma still remains to be determined. Areas covered The pharmacological rationale that explains why it is possible to use triple therapy in asthma and the results of clinical studies that have explored the effects of this therapy in asthmatics is critically examined. A systematic search was conducted on 10 August 2019, and included six electronic databases EMBASE, MEDLINE, Scopus, The Cochrane Library, Web of Science, and Google Scholar. Expert opinion The real role of single inhaler triple therapy in asthma will be demonstrated when the various trials that are currently ongoing or are scheduled will be completed. We believe that it is appropriate to treat with triple therapy asthmatic patients who have smoked and remain symptomatic or suffer from frequent exacerbations despite initial inhaler therapy with ICS/LABA. However, we must establish when to step up or mainly step down triple therapy especially in patients who are well controlled, and what will be the cost of these combinations in the management of asthma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Corticosteroides
/
Antagonistas Muscarínicos
/
Agonistas de Receptores Adrenérgicos beta 2
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Expert Rev Respir Med
Ano de publicação:
2019
Tipo de documento:
Article