Melibiosamine, a novel oligosaccharide, suppresses mitogen-induced IL-2 production via inactivation of NFAT and NF&#954;B in Jurkat cells.

Fujita, Kazuki; Tanaka, Susumu; Iizumi, Kyoichi; Akiyama, Shuri; Uchida, Kaoru; Ogata, Makoto; Aoki, Daichi; Hosomi, Osamu; Kubohara, Yuzuru

Melibiosamine, a novel oligosaccharide, suppresses mitogen-induced IL-2 production via inactivation of NFAT and NFκB in Jurkat cells.

Fujita, Kazuki; Tanaka, Susumu; Iizumi, Kyoichi; Akiyama, Shuri; Uchida, Kaoru; Ogata, Makoto; Aoki, Daichi; Hosomi, Osamu; Kubohara, Yuzuru.

Afiliação

Fujita K; Laboratory of Health and Life Science, Department of Health Science, Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, 270-1695, Japan.
Tanaka S; Department of Health and Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Takasaki, Gunma, 370-0033, Japan.
Iizumi K; Laboratory of Health and Life Science, Department of Health Science, Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, 270-1695, Japan.
Akiyama S; Department of Health and Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Takasaki, Gunma, 370-0033, Japan.
Uchida K; Department of Health and Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Takasaki, Gunma, 370-0033, Japan.
Ogata M; Department of Chemistry and Biochemistry, National Institute of Technology, Fukushima College, Iwaki, Fukushima, 970-8034, Japan.
Aoki D; Department of Chemistry and Biochemistry, National Institute of Technology, Fukushima College, Iwaki, Fukushima, 970-8034, Japan.
Hosomi O; Laboratory of Health and Life Science, Department of Health Science, Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, 270-1695, Japan.
Kubohara Y; Laboratory of Health and Life Science, Department of Health Science, Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, 270-1695, Japan.

Biochem Biophys Rep ; 19: 100658, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31431927

Palavras-chave

AP-1, activator protein 1; CIIP, ConA-induced IL-2 production; ConA, concanavalin A; CsA, cyclosporine A; GlcNH2, glucosamine; Glucosamine; IL-2, interleukin-2; IM, ionomycin; Immunosuppressive drug; Interleukin 2; Jurkat cell; MelNH2, melibiosamine; Melibiosamine; NFAT, nuclear factor of activated T-cells; NFκB, nuclear factor kappa-light-chain-enhancer of activated B cells; PIIP, PMA/IM-induced IL-2 production; PMA, phorbol 12-myristate 13-acetate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biochem Biophys Rep Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biochem Biophys Rep Ano de publicação: 2019 Tipo de documento: Article