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Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples.
Setién-Olarra, A; Marichalar-Mendia, X; Fernández-Pacheco, J-A; Fernández-Barriales-López, M; Gainza-Cirauqui, M-L; Aguirre-Urizar, J-M.
Afiliação
  • Setién-Olarra A; Oral Medicine, Oral and Maxillofacial Pathology, Department of Stomatology II, University of the Basque Country/ EHU, Leioa, 48940 Bizkaia, Spain, xabier.marichalar@gmail.com.
Med Oral Patol Oral Cir Bucal ; 24(5): e610-e614, 2019 Sep 01.
Article em En | MEDLINE | ID: mdl-31433395
BACKGROUND: To validate oral exfoliative cytology in the analysis of the microRNA expression profile in Oral Lichenoid Disease (OLD). MATERIAL AND METHODS: The expression of 13 microRNAs identified and presented by our group in a previous study was analyzed in 26 cases, 16 diagnosed as OLD and 10 controls with no oral mucosal pathology. Cytological samples from the oral mucosa obtained using an Orcellex toothbrush were analyzed using RT-qPCR and TaqMan microRNA assays. RESULTS: The aberrant expression was validated for 2 microRNAs (miR-146a-5p and miR-7-1-3p) of those previously recognized in the biopsy study. CONCLUSIONS: This is the first time that oral exfoliative cytology is validated in a study of the alterations of the expression of microRNAs in OLD. The alteration of miR-146a and miR-7 compared to controls was validated. These microRNAs are associated with both inflammatory and carcinogenic phenomena that are involved in the etiopathogenesis of this potentially malignant oral disorder.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Doenças da Boca Limite: Humans Idioma: En Revista: Med Oral Patol Oral Cir Bucal Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Doenças da Boca Limite: Humans Idioma: En Revista: Med Oral Patol Oral Cir Bucal Ano de publicação: 2019 Tipo de documento: Article