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Novel ADAM-17 inhibitor ZLDI-8 inhibits the proliferation and metastasis of chemo-resistant non-small-cell lung cancer by reversing Notch and epithelial mesenchymal transition in vitro and in vivo.
Lu, Hong-Yuan; Zu, Yu-Xin; Jiang, Xiao-Wen; Sun, Xiao-Tong; Liu, Tian-Yi; Li, Ruo-Lan; Wu, Qiong; Zhang, Ying-Shi; Zhao, Qing-Chun.
Afiliação
  • Lu HY; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, China.
  • Zu YX; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Jiang XW; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Sun XT; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Liu TY; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Li RL; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wu Q; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zhang YS; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: zhangyingshi526@163.com.
  • Zhao QC; Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, China. Electronic address: zhaoqingchun1967@163.com.
Pharmacol Res ; 148: 104406, 2019 10.
Article em En | MEDLINE | ID: mdl-31442576
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Proliferação de Células / Transição Epitelial-Mesenquimal / Proteína ADAM17 / Neoplasias Pulmonares / Metástase Neoplásica / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Proliferação de Células / Transição Epitelial-Mesenquimal / Proteína ADAM17 / Neoplasias Pulmonares / Metástase Neoplásica / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Ano de publicação: 2019 Tipo de documento: Article