Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma.

Okazaki, Shogo; Umene, Kiyoko; Yamasaki, Juntaro; Suina, Kentaro; Otsuki, Yuji; Yoshikawa, Momoko; Minami, Yushi; Masuko, Takashi; Kawaguchi, Sho; Nakayama, Hideki; Banno, Kouji; Aoki, Daisuke; Saya, Hideyuki; Nagano, Osamu

Okazaki, Shogo; Umene, Kiyoko; Yamasaki, Juntaro; Suina, Kentaro; Otsuki, Yuji; Yoshikawa, Momoko; Minami, Yushi; Masuko, Takashi; Kawaguchi, Sho; Nakayama, Hideki; Banno, Kouji; Aoki, Daisuke; Saya, Hideyuki; Nagano, Osamu.

Afiliação

Okazaki S; Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.
Umene K; Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
Yamasaki J; Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.
Suina K; Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
Otsuki Y; Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.
Yoshikawa M; Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.
Minami Y; Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.
Masuko T; Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan.
Kawaguchi S; Cell Biology Laboratory, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Higashiosaka, Japan.
Nakayama H; Cell Biology Laboratory, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Higashiosaka, Japan.
Banno K; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Aoki D; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Saya H; Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
Nagano O; Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.

Cancer Sci ; 110(11): 3453-3463, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31444923

Assuntos

Sistema y+ de Transporte de Aminoácidos/metabolismo; Glutationa/metabolismo; Neoplasias de Cabeça e Pescoço/metabolismo; Terapia de Alvo Molecular/métodos; Células-Tronco Neoplásicas/metabolismo; Carcinoma de Células Escamosas de Cabeça e Pescoço/metabolismo; Sistema ASC de Transporte de Aminoácidos/genética; Sistema y+ de Transporte de Aminoácidos/antagonistas & inibidores; Animais; Anti-Inflamatórios não Esteroides/farmacologia; Antineoplásicos/farmacologia; Adesão Celular; Diferenciação Celular; Linhagem Celular Tumoral; Cisplatino/farmacologia; Glutamato Desidrogenase/metabolismo; Glutamina/metabolismo; Neoplasias de Cabeça e Pescoço/tratamento farmacológico; Neoplasias de Cabeça e Pescoço/genética; Neoplasias de Cabeça e Pescoço/patologia; Humanos; Receptores de Hialuronatos/análise; Receptores de Hialuronatos/metabolismo; Ácidos Cetoglutáricos/metabolismo; Metaboloma; Camundongos; Camundongos Nus; Antígenos de Histocompatibilidade Menor/genética; Mitocôndrias/metabolismo; Oxirredução; Estresse Oxidativo; RNA Mensageiro/metabolismo; Carcinoma de Células Escamosas de Cabeça e Pescoço/tratamento farmacológico; Carcinoma de Células Escamosas de Cabeça e Pescoço/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia; Sulfassalazina/farmacologia

Palavras-chave

ASCT2; CD44 variant; glutamate dehydrogenase; head and neck cancer; xCT

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Sistema y/ de Transporte de Aminoácidos / Terapia de Alvo Molecular / Carcinoma de Células Escamosas de Cabeça e Pescoço / Glutationa / Neoplasias de Cabeça e Pescoço Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2019 Tipo de documento: Article

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