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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Clark, Charles G; Rossi, Karen A; Corte, James R; Fang, Tianan; Smallheer, Joanne M; De Lucca, Indawati; Nirschl, David S; Orwat, Michael J; Pinto, Donald J P; Hu, Zilun; Wang, Yufeng; Yang, Wu; Jeon, Yoon; Ewing, William R; Myers, Joseph E; Sheriff, Steven; Lou, Zhen; Bozarth, Jeffrey M; Wu, Yiming; Rendina, Alan; Harper, Timothy; Zheng, Joanna; Xin, Baomin; Xiang, Qian; Luettgen, Joseph M; Seiffert, Dietmar A; Wexler, Ruth R; Lam, Patrick Y S.
Afiliação
  • Clark CG; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States. Electronic address: charles.clark@bms.com.
  • Rossi KA; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Corte JR; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Fang T; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Smallheer JM; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • De Lucca I; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Nirschl DS; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Orwat MJ; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Pinto DJP; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Hu Z; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Wang Y; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Yang W; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Jeon Y; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Ewing WR; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Myers JE; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Sheriff S; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Lou Z; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Bozarth JM; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Wu Y; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Rendina A; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Harper T; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Zheng J; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Xin B; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Xiang Q; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Luettgen JM; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Seiffert DA; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Wexler RR; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
  • Lam PYS; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543, United States.
Bioorg Med Chem Lett ; 29(19): 126604, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31445854
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Fator XIa / Inibidores de Serina Proteinase / Compostos Macrocíclicos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Fator XIa / Inibidores de Serina Proteinase / Compostos Macrocíclicos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2019 Tipo de documento: Article