Toward a unified theory of aging and regeneration.
Regen Med
; 14(9): 867-886, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31455183
ABSTRACT
Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic-fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic cells to pluripotency demonstrates the possibility of restoring telomerase and embryonic regeneration pathways and thus reversing the age-related decline in regenerative capacity. A unified model of aging and loss of regenerative potential is emerging that may ultimately be translated into new therapeutic approaches for establishing induced tissue regeneration and modulation of the embryo-onco phenotype of cancer.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Envelhecimento
/
Modelos Biológicos
Limite:
Humans
Idioma:
En
Revista:
Regen Med
Ano de publicação:
2019
Tipo de documento:
Article